Study M779
Study name | Ciocan D 2021 |
Title | Blood microbiota and metabolomic signature of major depression before and after antidepressant treatment: a prospective case-control study |
Overall design | The aim of this study was to investigate whether a distinct blood microbiome and metabolome was associated with major depressive episodes, and how it was modulated by treatment. In this case-control multiomic study, authors analyzed the blood microbiome composition, inferred bacterial functions and metabolomic profile of 56 patients experiencing a current major depressive episode (depression group) and 56 matched healthy controls (control group), before and after 3-month treatment, using 16S rDNA sequencing and liquid chromatography coupled to tandem mass spectrometry. Response to treatment was defined by a decrease of greater than 50% in HDRS score after 3 months of treatment. Remitters were those with an HDRS score of less than 7 after 3 months of treatment. |
Study Type | Type1; Type2; Type4; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV-TR diagnosed MDD, HAMD-17 >= 18 |
Sample size | 112 |
Tissue | Peripheral; Blood; Plasma; |
Platform | MS-based; LC-MS: not reported; |
PMID | |
DOI | |
Citation | Ciocan D, Cassard AM, Becquemont L, et al. Blood microbiota and metabolomic signature of major depression before and after antidepressant treatment: a prospective case-control study. J Psychiatry Neurosci. 2021 May 19;46(3):E358-E368. |
Metabolite | L-Tryptophan; L-Leucine; L-Serine; L-Threonine; L-Isoleucine; L-Methionine; L-Aspartic acid; L-Lysine; L-Tyrosine; L-Kynurenine; Creatinine; Taurine; Citrulline; L-Carnitine; Stearoylcarnitine; |
