Study M773

Study name

Mao Q 2021

Title

Serum metabolic profiling of late-pregnant women with antenatal depressive symptoms

Overall design

In this study, liquid chromatography-tandem mass spectrometry-based metabolomics platforms were used to conduct serum metabolic profiling of antenatal depression and non-antenatal depression. Sixty participants were recruited, subjects with an Edinburgh Postnatal Depression Scale (EPDS) >= 10 were defined as antenatal depression subjects (antenatal depression group, n = 20), whereas the non-antenatal depression group subjects with EPDS < 10 (non-antenatal depression group, n = 40).

Study Type

Type1;

Data available

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8295540/

Organism

Human;

Categories of depression

Depressive symptom; Depressive symptom; Depressive symptom;

Criteria for depression

EPDS >= 10

Sample size

60

Tissue

Peripheral; Blood; Serum;

Platform

MS-based; LC-MS: VanquishTM UHPLC system (Thermo Fisher Scientific, Waltham, MA, USA) with Q Exactive HFX mass spectrometer (Orbitrap MS, Thermo Fisher Scientific) system;

PMID

34305679

DOI

10.3389/fpsyt.2021.679451

Citation

Mao Q, Tian T, Chen J, et al. Serum metabolic profiling of late-pregnant women with antenatal depressive symptoms. Front Psychiatry. 2021 Jul 8;12:679451.

Metabolite

Glyceric acid;

Citric acid;

L-Phenylalanine;

L-Glutamic acid;

L-Serine;

Succinic acid;

Uridine;

Glycyl-Valine;

Choline;

Phenylacetylglycine;

Hypoxanthine;

Betaine;

Cholesta-4,6-dien-3-one;

Cholesterol;

Glycerophosphocholine;

PC(32:0);

Hexanoylcarnitine;

Dodecanoylcarnitine;

Valeric acid;

3-Methyl-2-oxovaleric acid;

L-Norleucine;

2-Ketobutyric acid;

Tetrahydroaldosterone-3-glucuronide;

N-Acetyl-L-phenylalanine;

20-Hydroxyeicosatetraenoic acid;

5-HETE;

Formylanthranilic acid;

LysoPC(P-18:1(9Z));

Leukotriene B4;

alpha-Hydroxytamoxifen;

Desglucocheirotoxin;

Arginylvaline;

2,6 Dimethylheptanoyl carnitine;

1,9-Nonanedithiol;

Fludarabine;

1-Pyrroline;

1-Methyl-1,3-cyclohexadiene;

Hydroxypyruvic acid;

Acetone cyanohydrin;

4-Guanidinobutanoic acid;

apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)];

Acrylic acid;

2-Hydroxymyristic acid;

Isoleucyl-Phenylalanine;

Glycyl-Histidine;

Mitomycin;

1-Pyrroline-2-carboxylic acid;

1-O-2'-Hydroxy-4'-methoxycinnamoyl-b-D-glucose;

3-Feruloyl-1,5-quinolactone;

Nivalenol;

Disialosyl galactosyl globoside;

2-(3,4-Dihydroxyphenylethyl)-6-epi-elenaiate;

Honyucitrin;

Calcitriol;

2,3-Dinor-6-keto-prostaglandin F1 a;

3-(1,1-Dimethylallyl)scopoletin 7-glucoside;

Bortezomib;

Sofalcone;

9-OxoODE;

Glycerol tripropanoate;

Prostaglandin A2;

Ustiloxin D;

Phenylalanylthreonine;

2-Ethyl-2-Hydroxybutyric acid;

Histidylserine;

Aeglin;

Foeniculoside VII;

Isoleucyl-Leucine;

Prostaglandin F3a;

N-Acetylmuramoyl-Ala;

Diethyl phthalic acid;

Ssioriside;

Betamethasone;

Tamsulosin;

Asparaginylarginine;

Kanzonol I;

Fluocinolone Acetonide;

Lipoxin B4;

Ceanothine E;