Study M749
Study name | Teng T 2021a |
Title | Chronic unpredictable mild stress produces depressive-like behavior, hypercortisolemia, and metabolic dysfunction in adolescent cynomolgus monkeys |
Overall design | In this study, we adapted a chronic unpredictable mild stress (CUMS) paradigm used in rodent models of depression to induce depressive-like behavior in adolescent cynomolgus monkeys. Cynomolgus monkeys were divided into the following 2 groups (n = 5 in each group): (1) control group, and (2) CUMS group. The CUMS stress procedure was adapt from rodent studies. The CUMS group was exposed to seven days of chronic unpredictable mild stressors followed by a four-day behavior observation period; this regimen was conducted for five cycles. Metabolic profiling of plasma was performed using LC-MS. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Non-human primate; Cynomolgus monkey; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Behavioral observation |
Sample size | 10 |
Tissue | Peripheral; Blood; Plasma; |
Platform | MS-based; LC-MS: ultra-high performance liquid chromatography (1290 Infinity LC, Agilent Technologies) coupled to a quadrupole time-of-flight (AB SciexTripleTOF 6600); |
PMID | |
DOI | |
Citation | Teng T, Shively CA, Li X, et al. Chronic unpredictable mild stress produces depressive-like behavior, hypercortisolemia, and metabolic dysfunction in adolescent cynomolgus monkeys. Transl Psychiatry. 2021 Jan 4;11(1):9. |
Metabolite | Glyceric acid; Citric acid; Pyroglutamic acid; Stearic acid; L-Methionine; Cholic acid; dGTP; Hydroxyisocaproic acid; L-Acetylcarnitine; Malonic acid; D-Mannose; dGDP; SM(d18:1/18:0); Dihydroxyacetone; gamma-Glutamylglutamic acid; Uridine diphosphate-N-acetylglucosamine; Urocanic acid; D-Glucaric acid; D-Ornithine; Galactose 1-phosphate; Cyclohexylamine; N2-Acetylornithine; 3-Methoxy-4-Hydroxyphenylglycol sulfate; Ethyl (±)-3-hydroxybutyrate; Phosphoadenosine phosphosulfate; |
