Study M715
Study name | Yang J 2020 |
Title | Landscapes of bacterial and metabolic signatures and their interaction in major depressive disorders |
Overall design | The aim of this study was to investigate the landscapes of bacterial and metabolic signatures and their interaction in major depressive disorders. A total of 118 patients with major depressive disorder (MDD group) and 118 healthy controls (control group) were recruited. Gas chromatography-mass spectrometry (GC-MS)-based fecal metabolomics analysis was performed. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV diagnosed MDD |
Sample size | 236 |
Tissue | Peripheral; Faece; Faece; |
Platform | MS-based; GC-MS: Agilent 7890A/5975C GC-MS; |
PMID | |
DOI | |
Citation | Yang J, Zheng P, Li Y, et al. Landscapes of bacterial and metabolic signatures and their interaction in major depressive disorders. Sci Adv. 2020;6(49):eaba8555. |
Metabolite | Gamma-Aminobutyric acid; Pyroglutamic acid; Palmitic acid; L-Leucine; L-Proline; Homovanillic acid; D-Fructose; Sebacic acid; L-Cystine; 4-Hydroxyproline; Isocitric acid; alpha-D-Glucose; Tryptophanol; Adenosine monophosphate; Inosinic acid; Quinolinic acid; Pipecolic acid; Glutathione; Thymine; Phosphate; O-Phosphoethanolamine; L-Homoserine; Beta-mannosylglycerate; Hydrocinnamic acid; 2-Indolecarboxylic acid; Terephthalic acid; 5-(2-Hydroxyethyl)-4-methylthiazole; N2-Acetylornithine; Ibuprofen; Ciliatine; Edetic acid; 4-Methylbenzenesulfonamide; N-{2-hydroxyethyl}tetradecan-1-amine; Biphenyl; Itaconic acid; 1,3,5-Benzetriol; 5,7-Dimethyl[1,2,4]triazolo[1,5-a]pyrimidin-2-ylamine; Benzylamine; Erythronic acid lactone; Triacetin; Norvaline; Z Hexose; Altrose; Amidosulfonic acid; |
