Study M669
Study name | Xie XX 2020a |
Title | Depression-like behaviors are accompanied by disrupted mitochondrial energy metabolism in chronic corticosterone-induced mice |
Overall design | The aim of this study was to investigate the changes of depression-like behaviors and mitochondrial energy metabolism induced by chronic corticosterone. C57BL/6J mice were divided into the following 2 groups (n = 8 in each group): (1) control group, and (2) corticosterone group (corticosterone administered subcutaneously daily at the dose of 20 mg/kg for 6 weeks). Six liver samples per group were used for metabonomic analysis. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Mouse; C57BL/6J mouse; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Tail suspension test, forced swimming test |
Sample size | 12 |
Tissue | Peripheral; Liver; Liver; |
Platform | MS-based; GC-MS: Agilent 7890 gas chromatograph system (Agilent Technologies, Palo Alto, Calif.) with Pegasus HT time-of-flight mass spectrometer (AB Sciex, Foster City, CA, USA); |
PMID | |
DOI | |
Citation | Xie X, Shen Q, Yu C, et al. Depression-like behaviors are accompanied by disrupted mitochondrial energy metabolism in chronic corticosterone-induced mice. J Steroid Biochem Mol Biol. 2020;200:105607. |
Metabolite | Linoleic acid; Oleic acid; Stearic acid; Palmitoleic acid; Palmitic acid; L-Phenylalanine; L-Tryptophan; L-Leucine; L-Proline; L-Serine; L-Isoleucine; L-Glutamine; L-Lysine; L-Tyrosine; Ascorbic acid; Creatine; |
