Low neuroactive steroids identifies a biological subtype of depression in adults with human immunodeficiency virus on suppressive antiretroviral therapy
Overall design
The aim of this study was to identify plasma metabolites associated with depressive symptoms in people with human immunodeficiency virus (HIV) receiving antiretroviral therapy (ART). This is a prospective study of ART-treated HIV-infected adults with (ART-treated HIV with depressive symptom group) or without depressive symptoms (ART-treated HIV without depressive symptom group) assessed using longitudinal Beck Depression Inventory scores. Plasma metabolite profiling was performed in 2 independent cohorts (total n = 99) using liquid and gas chromatography and tandem mass spectrometry. In the discovery cohort, 17 and 38 participants were classified as high and low depressive symptoms, respectively. In the validation cohort, 18 and 26 participants were classified as high and low depressive symptoms, respectively.
Study Type
Type1;
Data available
Unavailable
Organism
Human;
Categories of depression
Depressive symptom; Depressive symptom with comorbidity; Depressive symptom with comorbidity;
Mukerji SS, Misra V, Lorenz DR, et al. Low neuroactive steroids identifies a biological subtype of depression in adults with human immunodeficiency virus on suppressive antiretroviral therapy. J Infect Dis. 2020;jiaa104.
