Study M629
Study name | Li SF 2020 |
Title | Antidepressant-like effects of coumaroylspermidine extract from safflower injection residues |
Overall design | The aim of this study was to investigate the antidepressant effects of coumaroylspermidine extract (CSE) using the chronic unpredictable mild stress (CUMS) model. Sprague-Dawley rats were divided into the following 5 groups (n = 10 in each group): (1) control group, (2) CUMS group, (3) CUMS + venlafaxine group (stressor plus venlafaxine treatment at the dose of 35 mg/kg), (4) CUMS + middle dose of coumaroylspermidine extract group (stressor plus coumaroylspermidine extract treatment at the dose of 17.3 mg/kg), and (5) CUMS + high dose of coumaroylspermidine extract group (stressor plus coumaroylspermidine extract treatment at the dose of 34.6 mg/kg). The CUMS stress procedure lasted for 4 weeks, and drugs were administered via intragastric once per day during the model building period. The monoamine neurotransmitters levels in the hippocampus were detected by a LC-MS/MS-IT-TOF. H-NMR spectrometry of the serum was measured with a Bruker 600-MHz Spectrometer. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test, forced swimming test |
Sample size | 50 |
Tissue | Peripheral; Blood; Serum; Central; Brain; Hippocampus; |
Platform | MS-based; LC-MS: LS-MS/MS-IT-TOF machine; NMR; NMR: Bruker 600-MHz Spectrometer (Bruker, Germany); |
PMID | |
DOI | |
Citation | Li S, Li T, Jin Y, et al. Antidepressant-like effects of coumaroylspermidine extract from safflower injection residues. Front Pharmacol. 2020;11:713. |
Metabolite | Gamma-Aminobutyric acid; L-Tryptophan; L-Glutamic acid; L-Isoleucine; L-Lactic acid; L-Alanine; L-Tyrosine; 5-Hydroxyindoleacetic acid; Choline; Serotonin; |
