Study M611
Study name | Geng CM 2020c |
Title | Comprehensive evaluation of lipopolysaccharide-induced changes in rats based on metabolomics |
Overall design | In this study, a comprehensive metabolomics-based analysis of the serum, liver, kidney, hippocampus, and heart following exposure to lipopolysaccharide (LPS) was performed. Sprague-Dawley rats were divided into the following 2 groups (n = 8 in each group): (1) control group, and (2) LPS group (500 ug/kg of LPS injection every other day for 14 days). Gas chromatography-mass spectrometry (GC-MS) was used for metabolite determination. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Lipopolysaccharide induced depression model; Lipopolysaccharide induced depression model; |
Criteria for depression | Not reported |
Sample size | 16 |
Tissue | Peripheral; Blood; Serum; Peripheral; Heart; Heart; Peripheral; Liver; Liver; Central; Brain; Hippocampus; Peripheral; Kidney; Kidney; |
Platform | MS-based; GC-MS: 7890B GC system with 7000C mass spectrometer; |
PMID | |
DOI | |
Citation | Geng C, Guo Y, Wang C, et al. Comprehensive evaluation of lipopolysaccharide-induced changes in rats based on metabolomics. J Inflamm Res. 2020;13:477-486. |
Metabolite | myo-Inositol; Glycerol; Pyroglutamic acid; Stearic acid; Palmitoleic acid; Palmitic acid; L-Tryptophan; L-Valine; L-Leucine; L-Proline; L-Glutamic acid; Glycine; L-Serine; L-Threonine; L-Isoleucine; L-Methionine; L-Alanine; L-Tyrosine; D-Glucose; Urea; Cholesterol; Oleamide; Acetamide; Propionic acid; Glycerol 1-hexadecanoate; D-Lactic acid; |
