Study M598
Study name | Cui YF 2020 |
Title | Early-life stress induces depression-like behavior and synaptic-plasticity changes in a maternal separation rat model: gender difference and metabolomics study |
Overall design | The aim of this study was to explore the mechanism of the maternal separation (MS) rat model in depression-like behavior in adult rats. Sprague-Dawley rats were divided into the following 4 groups: (1) male control group, (2) male MS group, (3) female control group, and (4) female MS group. From postnatal day (PND) 1 to 21, the pups of the MS groups were separated from their dams for 6 hours daily. Effect of MS on sex hormones and their metabolites was investigated by LC-MS. Differential metabolites in brain tissues were investigated by LC-MS-based untargeted metabolomics analysis. Six samples per group were used for metabonomic analysis. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Sucrose preference test, forced swimming test |
Sample size | 18 |
Tissue | Central; Brain; Brain; |
Platform | MS-based; LC-MS: Agilent 1290 Infinity LC UPLC system with Aglient-QTOF/MS-6545 mass spectrometer; |
PMID | |
DOI | |
Citation | Cui Y, Cao K, Lin H, et al. Early-life stress induces depression-like behavior and synaptic-plasticity changes in a maternal separation rat model: gender difference and metabolomics study. Front Pharmacol. 2020;11:102. |
Metabolite | myo-Inositol; Arachidonic acid; Pantothenic acid; Glycerophosphocholine; Phosphoenolpyruvic acid; Glutathione; Deoxycholic acid glycine conjugate; 5-Hydroxy-L-tryptophan; Anandamide; Palmitoylethanolamide; 15-HETE; Pantetheine 4'-phosphate; Tryptamine; L-Glutamic acid 5-phosphate; Lysylhistidine; Beta-Aminopropionitrile; D-Pantothenoyl-L-cysteine; LysoPC(20:1(11Z)); (S)-Methylmalonic acid semialdehyde; Methionyl-Glutamate; Methionyl-Glutamine; Cysteinyl-Phenylalanine; PE(14:1(9Z)/P-18:1(9Z)); Phenylalanylisoleucine; |
