Study M573
Study name | Yang LN 2019 |
Title | Integrated metabolomics and proteomics analysis revealed second messenger system disturbance in hippocampus of chronic social defeat stress rat |
Overall design | In this study, we combined a non-targeted gas chromatography-mass spectrometry-based metabolomic approach and isobaric tags for relative and absolute quantitation (iTRAQ)-based proteomic analysis to elucidate metabolite and protein alterations in the hippocampus of rat after chronic social defeat stress (CSDS), an extensively used animal model of depression. Sprague-Dawley rats were divided into the following 2 groups: (1) control group (n = 8), and (2) CSDS group (n = 9). The CSDS stress procedure lasted for 3 weeks. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Social defeat model; Social defeat model; |
Criteria for depression | Sucrose preference test, forced swimming test |
Sample size | 17 |
Tissue | Central; Brain; Hippocampus; |
Platform | MS-based; GC-MS: Agilent 7890A/5975C GC/MSD System (Agilent Technologies Inc., USA); |
PMID | |
DOI | |
Citation | Yang LN, Pu JC, Liu LX, et al. Integrated metabolomics and proteomics analysis revealed second messenger system disturbance in hippocampus of chronic social defeat stress rat. Front Neurosci. 2019;13:247. |
Metabolite | myo-Inositol; Gamma-Aminobutyric acid; Glycerol; Pyroglutamic acid; N-Acetyl-L-aspartic acid; L-Glutamic acid; Glycine; L-Serine; Arachidonic acid; L-Methionine; L-Lactic acid; L-Alanine; L-Aspartic acid; Ethanolamine; D-Ribose; Inosine; 3-Phosphoglyceric acid; Aminomalonic acid; Phosphate; |
