Study M569
Study name | Wang CZ 2019 |
Title | Effects of Platycodins Folium on depression in mice based on a UPLC-Q/TOF-MS serum assay and hippocampus metabolomics |
Overall design | The aim of this study was to investigate the antidepressant effect of Platycodins Folium (PF) using lipopolysaccharide (LPS)-induced depressive mice. ICR mice were divided into the following 3 groups: (1) control group, (2) LPS group (LPS injection), and (3) LPS + HPF group (LPS injection plus PF treatment at the dose of 400 mg/kg). All the mice were administered their respective solutions once daily (i.g. 10 mL/kg) for 7 consecutive days. On the 7th day, all mice received a single LPS (0.83 mg/kg, i.p.) or vehicle after the last drug treatment. A UPLC-Q/TOF-MS-based metabolomics approach was applied to explore the latent mechanism of PF in attenuating depression. Eight samples per group were used for metabonomic analysis. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Mouse; ICR mouse; |
Categories of depression | Animal model; Lipopolysaccharide induced depression model; Lipopolysaccharide induced depression model; |
Criteria for depression | Sucrose preference test, forced swimming test, tail suspension test |
Sample size | 24 |
Tissue | Peripheral; Blood; Serum; Central; Brain; Hippocampus; |
Platform | MS-based; LC-MS: UPLC system with Waters Xevo G2-XS QTOF mass spectrometer (Waters Co., Milford, MA, USA); |
PMID | |
DOI | |
Citation | Wang C, Lin H, Yang N, et al. Effects of Platycodins Folium on depression in mice based on a UPLC-Q/TOF-MS serum assay and hippocampus metabolomics. Molecules. 2019;24(9):1712. |
Metabolite | myo-Inositol; Citric acid; Linoleic acid; L-Tryptophan; Arachidonic acid; Pantothenic acid; Phytosphingosine; Oxoglutaric acid; Indoleacetaldehyde; Oxidized glutathione; Glycerophosphocholine; Glutathione; Sphingosine 1-phosphate; PC(16:0/18:1); Sphinganine; Sphinganine 1-phosphate; Prostaglandin H2; Leukotriene A4; 12,13-EpOME; 19(S)-HETE; LysoPC(18:1(9Z)); PC(18:1/18:2); |
