Study M522
Study name | Li JG 2018 |
Title | Short term intrarectal administration of sodium propionate induces antidepressant-like effects in rats exposed to chronic unpredictable mild stress |
Overall design | This study uses GC-MS spectrometry and a combination of static and dynamic metabolomics data analysis to study the typical gut metabolites of rats with depression-like behaviors. Propionic acid was observed by both static and dynamic metabolomics data analysis, and intervention with NaP (the salt form of propionic acid) was carried out to study the effects of propionic acid on depression. Rats were divided into the following 4 groups (n = 6 in each group): (1) control group, (2) CUMS group, (3) CUMS + PBS group (stressor plus PBS), and (4) CUMS + NaP group (stressor plus 1 mL of NaP (200 mmol/L) in PBS treatment). The CUMS stress procedure lasted for 5 weeks, and drugs were administered via intragastric once per day during the last week of the model building period. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test |
Sample size | 24 |
Tissue | Peripheral; Faece; Faece; Central; Brain; Prefrontal cortex; |
Platform | MS-based; GC-MS: trace gas chromatograph coupled with a Polyris Q Ion Trap mass spectrometer (Thermo Fisher Scientific, MA, USA); MS-based; LC-MS: Thermo Scientific Dionex Ultimate 3000 RSLC system combined with a ThermoQ Exactive Orbitrap mass spectrometer; |
PMID | |
DOI | |
Citation | Li J, Hou L, Wang C, et al. Short term intrarectal administration of sodium propionate induces antidepressant-like effects in rats exposed to chronic unpredictable mild stress. Front Psychiatry. 2018 Sep 27;9:454. |
Metabolite | Glycerol; Glutaric acid; L-Tryptophan; L-Valine; L-Leucine; L-Proline; Glycine; L-Serine; L-Threonine; L-Isoleucine; L-Methionine; L-Lactic acid; L-Alanine; L-Aspartic acid; Homovanillic acid; Succinic acid; L-Kynurenine; 3,4-Dihydroxybenzeneacetic acid; Serotonin; Hydroxykynurenine; Norepinephrine; Dopamine; 3-Hydroxyanthranilic acid; Kynurenine/Tryptophan ratio; Propionic acid; 3-Methoxytyramine; Homovanillic acid/dopamine ratio; 3,4-Dihydroxybenzeneacetic acid/Dopamine ratio; |
