Study name | Li B 2018 |
Title | Metabolite identification in fecal microbiota transplantation mouse livers and combined proteomics with chronic unpredictive mild stress mouse livers |
Overall design | In this study, germ-free mice underwent fecal microbiota transplantation from major depressive disorder (MDD) patients and healthy controls. GF Mice were divided into the following 2 groups (n = 12 in each group): (1) control group (fecal microbiota transplantation with fecal sample from healthy controls), (2) depressed group (fecal microbiota transplantation with fecal sample from major depression patients). Behavioral tests verified the depression model. Metabolomics using gas chromatography-mass spectrometry, nuclear magnetic resonance, and liquid chromatography-mass spectrometry determined the influence of microbes on liver metabolism. |
Study Type  | Type1;
|
Data available | Unavailable |
Organism | Mouse; Kunming mouse;
|
Categories of depression | Animal model; Other animal model; Other animal model;
|
Criteria for depression | Forced swimming test, tail suspension test |
Sample size | 24 |
Tissue | Peripheral; Liver; Liver;
|
Platform | MS-based; GC-MS: Agilent 7890A/5975C (Agilent Technologies, Santa Clara, CA, USA); MS-based; LC-MS: Agilent 6538 UHD and Accurate-Mass Q-TOF/MS (Agilent Technologies, Santa Clara, CA, USA); NMR; NMR: Bruker AVANCE II 600 (Bruker Biospin, Rheinstetten, Germany); |
PMID | 29382834 |
DOI | 10.1038/s41398-017-0078-2 |
Citation | Li B, Guo K, Zeng L, et al. Metabolite identification in fecal microbiota transplantation mouse livers and combined proteomics with chronic unpredictive mild stress mouse livers. Transl Psychiatry 2018;8(1):34. |
Metabolite | Glycerol;
Pyroglutamic acid;
3-Hydroxybutyric acid;
L-Valine;
L-Proline;
Glycine;
Arachidonic acid;
L-Isoleucine;
L-Lactic acid;
L-Alanine;
L-Glutamine;
L-Lysine;
Succinic acid;
Uridine;
Urea;
Hypoxanthine;
Xanthine;
Ethanolamine;
Uracil;
Beta-D-Glucose;
Trimethylamine N-oxide;
L-Histidine;
Inosine;
alpha-D-Glucose;
Phosphorylcholine;
3-Aminoisobutanoic acid;
LysoPC(18:2);
PC(O-38:5);
Putrescine;
Glycerol 3-phosphate;
Glutathione;
Glycogen;
PC(32:0);
O-Phosphoethanolamine;
Fosfomycin;
SM(d18:1/16:0);
D-Arabitol;
Alpha-Linolenic acid;
SM(d18:1/18:0);
PC(16:0/18:0);
Phosphocreatine;
Dephospho-CoA;
Cer(d18:1/16:0);
Glycerol 1-hexadecanoate;
LysoPC(18:2(9Z,12Z));
LysoPC(18:3(6Z,9Z,12Z));
LysoPC(20:4/0:0);
LysoPE(0:0/16:0);
Uridine diphosphate glucose;
Iminodiacetic acid;
Galactinol;
Maltotriitol;
Succinyladenosine;
Prenyl arabinosyl-(1->6)-glucoside;
Carvedilol(p-Hydroxy);
Deoxydaunorubicinolaglycone -13-O-b-glucuronide;
N-Adenylyl-L-phenylalanine;
alpha,beta-Dihydroxanthohumol;
6-bromo-heneicosa-5E,9Z-dienoic acid;
Jurubine;
PS(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/0:0);
PS(15:0/22:0);
2(alpha-D-Mannosyl)-D-glycerate;
PE(16:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z));
LysoPE(0:0/18:2(9Z,12Z));
PT(18:0/18:1(9Z));
Dihydrocaffeic acid 3-O-glucuronide;
LysoPE(20:4(5Z,8Z,11Z,14Z)/0:0);
(25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-27-oyl taurine;
LysoPC(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/0:0);
LysoPE(0:0/18:0);
PS(18:3(6Z,9Z,12Z)/21:0);
LysoPE(20:2(11Z,14Z)/0:0);
Dihydroergocornine;
LysoPE(18:0/0:0);
PS(19:1(9Z)/22:4(7Z,10Z,13Z,16Z));
Tumonoic Acid I;
PI(18:0/0:0);
LysoPE(16:0/0:0);
LysoPI(20:4(5Z,8Z,11Z,14Z)/0:0);
Allodesmosine;
LysoPE(22:4(7Z,10Z,13Z,16Z)/0:0);
21-Deoxycortisone;
LysoPC(0:0/20:4(5Z,8Z,11Z,14Z));
LysoPC(18:0/0:0);
PC(15:0/0:0);
LysoPE(18:3(9Z,12Z,15Z)/0:0);
1-heptadecanoyl-sn-glycero-3-Phosphocholine;
LysoPE(0:0/20:0);
PC(18:1(6Z)/0:0);
LysoPE(0:0/20:3(11Z,14Z,17Z));
FAD;
PG(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z));
1-arachidonoyl-2-hydroxy-sn-glycero-3-phosphate;
Vitamin D3 sulfoconjugate;
CDP-DG(16:0/18:1(11Z));
CDP-DG(18:1(11Z)/18:2(9Z,12Z));
3-Hexaprenyl-4,5-Dihydroxybenzoic acid;
DG(18:1(11E)/16:0/0:0);
(3beta,5alpha,6beta,24R)-Stigmastane-3,5,6-triol;
N-Hexadecanoyl-tryptophan;
Vitamin D3 palmitate;
1--2-acetyl-sn-glycerol;
13-beta-D-Glucosyloxydocosanoate;
Ubiquinone-4;
Feruloylacetyl-CoA;
3-trans,5-cis-Octadienoyl-CoA;
PC(18:0/18:2(10Z,12Z));
Nicotinic acid adenine dinucleotide;
LysoPE(18:3(6Z,9Z,12Z)/0:0);
PI(18:0/22:0);
PE(18:1(11Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z));
PI(P-20:0/19:1(9Z));
PS(15:1(9Z)/22:4(7Z,10Z,13Z,16Z));
LysoPE(0:0/20:3(5Z,8Z,11Z));
PE(16:0/22:5(4Z,7Z,10Z,13Z,16Z));
PI(20:0/18:0);
PI(16:0/20:0);
PC(20:5(5Z,8Z,11Z,14Z,17Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z));
PC(16:0/18:2(11Z,13Z));
O-Arachidonoylglycidol;
PIP(16:0/18:1(11Z));
LysoPC(20:3(8Z,11Z,14Z)/0:0);
PI(20:5(5Z,8Z,11Z,14Z,17Z)/0:0);
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