Study M148
Study name | Jia HM 2017 |
Title | Chaihu-Shu-Gan-San regulates phospholipids and bile acid metabolism against hepatic injury induced by chronic unpredictable stress in rat |
Overall design | In this study, the protection of Chaihu-Shu-Gan-San (CSGS) against hepatic injury induced by chronic unpredicted mild stress (CUMS) treatment was explored by metabonomics study and gene expression of the rat liver tissue. All the rats were divided into the following 4 groups (n = 10 in each group): (1) control group, (2) CUMS group, (3) CUMS + CSGS group (stressor plus CSGS treatment at the dose of 2.5 g/kg), and (4) CUMS + fluoxetine group (stressor plus fluoxetine treatment at the dose of 20 mg/kg). The CUMS stress procedure lasted for 4 weeks, and drugs were administered orally once per day during the model building period. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Rat; Wistar rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test |
Sample size | 40 |
Tissue | Peripheral; Liver; Liver; |
Platform | MS-based; LC-MS: Waters ACQUITY UPLC System with SYNAPT HDMS system Q-TOF analyzer; |
PMID | |
DOI | |
Citation | Jia HM, Yu M, Ma LY, et al. Chaihu-Shu-Gan-San regulates phospholipids and bile acid metabolism against hepatic injury induced by chronic unpredictable stress in rat. J Chromatogr B Analyt Technol Biomed Life Sci 2017; 1064:14-21. |
Metabolite | Gamma-Aminobutyric acid; Oleic acid; Niacinamide; Glycerophosphocholine; L-Carnitine; PC(36:4); PE(36:4); Taurochenodesoxycholic acid; PC(36:2); |
