Study M1097

Study name

Zhu RZ 2023

Title

Psychobiotic Lactobacillus plantarum JYLP-326 relieves anxiety, depression, and insomnia symptoms in test anxious college via modulating the gut microbiota and its metabolism

Overall design

The aim of this study was to evaluate the potential effects of Lactobacillus plantarum JYLP-326 on test anxious college students. Sixty anxious students were enrolled and randomly allocated to the placebo group (placebo-treated depression group; n =30) and the probiotic group (probiotic-treated depression group; n =30). Both groups were instructed to take placebo or JYLP-326 products twice per day for three weeks, respectively. Unanxious students with no treatments were assigned to a regular control group (control group; n =30). Fecal samples were used for metabonomic analysis.

Study Type

Type1;

Type2;

Data available

https://www.metabolomicsworkbench.org/data/DRCCMetadata.php?Mode=Study&StudyID=ST002475

Organism

Human;

Categories of depression

Depressive symptom; Depressive symptom with comorbidity; Depressive symptom with comorbidity;

Criteria for depression

HAMD-17 >= 8

Sample size

90

Tissue

Peripheral; Faece; Faece;

Platform

MS-based; LC-MS: UHPLC (1290 Infinity LC, Agilent Technologies) with quadrupole time-of-flight (AB Sciex TripleTOF 6600);

PMID

37033942

DOI

10.3389/fimmu.2023.1158137

Citation

Zhu R, Fang Y, Li H, et al. Psychobiotic Lactobacillus plantarum JYLP-326 relieves anxiety, depression, and insomnia symptoms in test anxious college via modulating the gut microbiota and its metabolism. Front Immunol. 2023 Mar 23;14:1158137.

Metabolite

Citric acid;

L-Glutamic acid;

L-Tyrosine;

D-Fructose;

L-Arginine;

Indoxyl sulfate;

Hypoxanthine;

Glucose 6-phosphate;

Betaine;

Gluconic acid;

L-Malic acid;

Glycerophosphocholine;

Isobutyric acid;

Nicotinic acid;

AICAR;

Riboflavin;

Allantoin;

Benzoic acid;

Tetradecanoylcarnitine;

Trigonelline;

Corticosterone;

Quinic acid;

Propionic acid;

Alpha-Linolenic acid;

Gluconolactone;

Urobilin;

Cer(d18:1/16:0);

3-Hydroxymethylglutaric acid;

LysoPC(18:0/0:0);

Glucaric acid;

1-Aminocyclopropanecarboxylic acid;

Cyclohexylamine;

C17 Sphinganine;

DL-Glutamate;

N-Acetylcadaverine;

Phenylacetylglutamine;

3-Methoxy-4-Hydroxyphenylglycol sulfate;

Ethyl (±)-3-hydroxybutyrate;

Pyridoxine;

4-Guanidinobutanoic acid;

LysoPE(18:1(9Z)/0:0);

Linoleoyl ethanolamide;

Norspermidine;

Hydroquinone;

Fructose 1-phosphate;

L-Gulonolactone;

Leukotriene E4;

Ethyl hydrogen sulfate;

3,3-Dimethylglutaric acid;

Tetraethylene glycol;

Aleuritic acid;

Nocardamine;

Daidzein 4'-sulfate;

Silibinin;

N-Acetyl-D-Glucosamine 6-Phosphate;

Mestranol;

Thymol-beta-d-glucoside;

Hydroquinidine;

D-Psicose;

(+)-3-(3,4-Methylenedioxyphenyl)-1,2-propanediol;

Daidzin;

Ostruthin;

1-hexadecyl-glycero-3-phosphate;

D-fructose 6-phosphate;

Famotidine propionic acid;

2-Oxo-4-methylthiobutanoic acid;

1,3,5,8-Tetrahydroxyxanthone;

1-palmitoyl-2-linoleoyl-sn-glycero-3-phospho-(1'-rac-glycerol);

6,8-dihydroxy-2,2,4,4-tetramethyl-7-(3-methylbutanoyl)-9-(2-methylpropyl)-9h-xanthene-1,3-dione;

2-keto-3-deoxyoctonic acid;

Lonchocarpol A;

Methyl (1-(cyclohexylmethyl)-1h-indole-3-carbonyl)-l-valinate;

(7'R)-(+)-Lyoniresinol 9'-glucoside;

Arcaine;

N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-1-pentyl-1h-indole-3-carboxamide;

Dibucaine;

N-acetylsphingosine;

2-dimethylamino-6-hydroxypurine;

2-(2-butoxyethoxy)acetic acid;

HC-Toxin;

17-trifluoromethylphenyltrinorprostaglandin f2alpha methyl ester;

Alpha-Linolenoyl ethanolamide;

17-trifluoromethylphenyltrinorprostaglandin f2alpha isopropyl ester;

Octaethylene glycol;

2-piperidinecarboxylic acid, 1-(3,3-dimethyl-1,2-dioxopentyl)-, (1r)-1-(3-aminophenyl)-3-(3,4-dimethoxyphenyl)propyl ester, (2s)-;

Mifepristone;

2,3-dinor-8-isoprostaglandin-f2alpha;

7,8-Dehydroastaxanthianthin;

2-Aminobenzamide;

5beta-androstan-3alpha-ol-17-one sulfate;

Biocytin;

Fenpropidin;

Carbofuran phenol-3-ketone;

Guaiacol methyl ether;

4alpha-hydroxystanozolol;

Cys-Trp-Arg;

Palmitoyl 3-carbacyclic phosphatidic acid;

RepSox;

Lappaconitine;

Glycerol tributanoate;

Cholestenone;

PE(15:0/15:0);

2-mohma;

Clorgiline;

Eplerenone hydroxy acid;

3-dehydroepiandrosterone sulfate;

7-Hydroxy Quetiapine;

Naringin dihydrochalcone;

HT-2 Toxin;

[6]-Shogaol;

3'-Hydroxydaidzein;

1,3-bis(tris(hydroxymethyl)methylamino)propane;

N-methyltryptamine;

ortho-Hydroxyphenylacetic acid;

11-Dehydro-thromboxane B2;

Mesoporphyrin IX;

3-Hydroxyoctanoic acid;

L-2-Hydroxyglutaric acid;

3-Indolebutyric acid;

1-palmitoyl-2-hydroxy-sn-glycero-3-phospho-(1'-rac-glycerol);

Celaxanthin;

Trp-Arg-Arg;

3-[(cholamidopropyl)dimethylammonio]-1-propanesulfonate;

Cycloate;

Pyroglu-Gly-Arg;

alpha-Methyltryptamine;