Study name | He XY 2017 |
Title | [Comparative study of the corticosterone and glutamate induced PC12 cells depression model by 1H NMR metabolomics] |
Overall design | This study was designed to analyze the change of metabolites in the PC12 cells and its medium induced by corticosterone (CORT) and glutamate (Glu) by proton nuclear magnetic resonance (1H NMR) metabolomics. PC12 cells depression model was induced by CORT and Glu. PC12 cells were divided into 3 groups (6 dishes in each group): (1) control group (no drug), (2) CORT group (PC12 cells treated with corticosterone 500 umol/L for 36 h), and (3) Glu group (PC12 cells treated with glutamate 20 mmol/L for 36 h). |
Type1; | |
Data available | Unavailable |
Organism | Rat; Rat; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Not reported |
Sample size | 18 |
Tissue | Central; Brain; PC12 cell; Central; Brain; PC12 cell medium; |
Platform | NMR; NMR: Bruker AVANCE III 600 spectrometer (Bruker Biospin, Rheinstetten, Germany); |
PMID | |
DOI | |
Citation | He X, Chen J, Xiang H, et al. [Comparative study of the corticosterone and glutamate induced PC12 cells depression model by 1H NMR metabolomics]. Yao Xue Xue Bao 2017;52(2):245-52. (Article in Chinese) |
Metabolite |