Study M1054
Study name | Jiang CF 2023 |
Title | [Study on antidepressant mechanism of Chaihuyujinxiang granules based on ultra-high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry] |
Overall design | The aim of this study was to explore the treatment mechanism of ChaihuYujinxiang granules in the chronic unpredictable mild stress (CUMS) model of depression. ICR mice were divided into the following 3 groups (n = 12 in each group): (1) control group, (2) CUMS group, and (3) CUMS + ChaihuYujinxiang granules group (stressor plus ChaihuYujinxiang granules treatment at the dose of 0.65 g/kg). The CUMS stress procedure lasted for 5 weeks, and drugs were administered via intragastric during the model building period. Ultra-high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry was used to investigate metabolomic profile in the plasma of mice (n =6/group). |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Mouse; ICR mouse; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test, forced swimming test |
Sample size | 18 |
Tissue | Peripheral; Blood; Plasma; |
Platform | MS-based; LC-MS: Agilent 1290 Infinity ultra-high performance liquid chromatography (Agilent) with AB Triple TOF 6600 mass spectrometry (AB SCIEX); |
PMID | |
DOI | |
Citation | Jiang CF, Xue GH, Zhang JQ, et al. [Study on antidepressant mechanism of Chaihuyujinxiang granules based on ultra-high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry]. Chinese Journal of Analytical Chemistry 2023;51(4):579-88. (Article in Chinese) |
Metabolite | Gamma-Aminobutyric acid; L-Phenylalanine; L-Tryptophan; L-Glutamic acid; Succinic acid; L-Tyrosine; Phytosphingosine; Taurine; |
