Study M1033
Study name | Chojnacki C 2022b |
Title | Antimicrobial treatment improves tryptophan metabolism and mood of patients with small intestinal bacterial overgrowth |
Overall design | The aim of this study was to assess the mental state and gastrointestinal complaints of patients with small intestinal bacterial overgrowth in relation to tryptophan metabolism and rifaximin treatment. The study involved 40 healthy people (control group), 40 patients with small intestinal bacterial overgrowth and chronic diarrhea (small intestinal bacterial overgrowth and chronic diarrhea group), and 40 patients with small intestinal bacterial overgrowth and chronic constipation (small intestinal bacterial overgrowth and chronic constipation group). Patients were mild and moderate depression based on HAMD scores. The concentrations of tryptophan and its metabolites in urine were determined using an LC-MS/MS method, before and after cyclic treatment with an antibiotic drug, rifaximin, for three months. Depression levels were ameliorated by rifaximin treatment in both groups. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive symptom; Depressive symptom with comorbidity; Depressive symptom with comorbidity; |
Criteria for depression | Not reported |
Sample size | 120 |
Tissue | Peripheral; Urine; Urine; |
Platform | MS-based; LC-MS: not reported; |
PMID | |
DOI | |
Citation | Chojnacki C, Poplawski T, Konrad P, et al. Antimicrobial treatment improves tryptophan metabolism and mood of patients with small intestinal bacterial overgrowth. Nutr Metab. 2022 Sep 27;19(1):66. |
Metabolite | L-Tryptophan; 5-Hydroxyindoleacetic acid; L-Kynurenine; Xanthurenic acid; |
