Study M1025
Study name | Feng SY 2023a |
Title | Bacillus licheniformis prevents and reduces anxiety-like and depression-like behaviours |
Overall design | The aim of this study was to explore whether Bacillus licheniformis could prevent and alleviate negative emotions (anxiety and depression) in chronic unpredictable mild stress (CUMS) model. Sprague-Dawley rats were divided into the following 3 groups: (1) control group, (2) CUMS group, and (3) CUMS + Bacillus licheniformis group (stressor plus Bacillus licheniformis treatment at the dose of 10^8 colony-forming units. The CUMS stress procedure lasted for 4 weeks, and drugs were administered via intragastric once per day during the model building period. Neurotransmitters in the whole brain were measured by liquid chromatography-mass spectrometry (n=6/group). Short chain fatty acids in the colon contents were detected by gas chromatography-mass spectrometry (n=6/group). |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Forced swimming test |
Sample size | 18 |
Tissue | Central; Brain; Brain; Peripheral; Faece; Faece; |
Platform | MS-based; LC-MS: high-performance LC with mass spectrometry; MS-based; GC-MS: not reported; |
PMID | |
DOI | |
Citation | Feng S, Meng C, Liu Y, et al. Bacillus licheniformis prevents and reduces anxiety-like and depression-like behaviours. Appl Microbiol Biotechnol. 2023 May 20. |
Metabolite | Gamma-Aminobutyric acid; |
