Study M084
Study name | Liu YS 2016 |
Title | Metabolomic biosignature differentiates melancholic depressive patients from healthy controls |
Overall design | In this study, a metabolomics method was applied to compare the plasma metabolomic biosignature from depressive patients (n = 90), including melancholic depressed patients (n = 21) and anxious depressed patients (n = 58), with healthy controls (n = 97). Metabolic profiling based on Gas chromatography-mass spectrometry (GC-MS) and Liquid chromatography-mass spectrometry (LC-MS/MS) was performed to investigate the metabolic changes between these groups. Data from melancholic depressed group (n = 21) vs. control group (n = 97) were reported. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive symptom; Depressive symptom; Depressive symptom; |
Criteria for depression | HAMD-17 >= 14 |
Sample size | 187 |
Tissue | Peripheral; Blood; Plasma; |
Platform | MS-based; GC-MS: Not reported; MS-based; LC-MS: Not reported; |
PMID | |
DOI | |
Citation | Liu Y, Yieh L, Yang T, et al. Metabolomic biosignature differentiates melancholic depressive patients from healthy controls. BMC Genomics 2016;17:669. |
Metabolite | Glyceric acid; myo-Inositol; Linoleic acid; Glycerol; Oleic acid; Stearic acid; Myristic acid; Palmitoleic acid; Palmitic acid; L-Phenylalanine; L-Cysteine; L-Valine; L-Leucine; Arachidonic acid; L-Isoleucine; L-Methionine; L-Alanine; Indole-3-propionic acid; L-Lysine; L-Tyrosine; L-Arginine; L-Cystine; Pseudouridine; Threonic acid; Urea; Cholic acid; LysoPC(16:0); Indoleacetic acid; Serotonin; Fumaric acid; Phosphatidylcholine; Histamine; Dopamine; Elaidic acid; Heptadecanoic acid; Glutamine/Glutamate ratio; 11Z-Eicosenoic acid; Androstenedione; Cer(d18:1/24:0); Corticosterone; Cortisol; Dodecanol; Metanephrine; Normetanephrine; Ribonic acid; TAG1; TAG2; TAG3; TAG4; TAG5; TAG6; TAG7; TAG8; TAG9; TAG10; PC(16:0/18:2); SM(d18:1/16:0); O-Phosphotyrosine; |
