Study M081
Study name | Jia HM 2016 |
Title | Chronic unpredictive mild stress leads to altered hepatic metabolic profile and gene expression |
Overall design | The aim of this study was to explore the metabolic profiles of hepatic extracts from rats treated with chronic unpredictive mild stress (CUMS) by UPLC-Q-TOF/MS. Twenty rats were divided into 2 groups: (1) control group, (2) CUMS group. Six samples per group were used for metabonomic analysis. The CUMS stress procedure lasted for 4 weeks. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Wistar rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Not reported |
Sample size | 12 |
Tissue | Peripheral; Liver; Liver; |
Platform | MS-based; LC-MS: Waters ACQUITY UPLC System with Q-TOF analyzer in a SYNAPT HDMS system (Waters Corporation, Milford, MA, USA); |
PMID | |
DOI | |
Citation | Jia HM, Li Q, Zhou C, et al. Chronic unpredictive mild stress leads to altered hepatic metabolic profile and gene expression. Sci Rep 2016;6:23441. |
Metabolite | Gamma-Aminobutyric acid; Oleic acid; Hypoxanthine; Creatine; Niacinamide; L-Acetylcarnitine; Glycerophosphocholine; L-Carnitine; PC(36:4); Isobutyryl-L-carnitine; Isovalerylcarnitine; PE(36:4); Taurochenodesoxycholic acid; PC(36:2); PA(44:3); PG(P-18:0/22:4); TG(45:2); PC(36:3); |
