Study M002
Study name | Ni Y 2008 |
Title | Metabolic profiling reveals disorder of amino acid metabolism in four brain regions from a rat model of chronic unpredictable mild stress |
Overall design | The aim of this study was to perform a GC/MS-based metabolic profiling approach to investigate neurochemical changes in the cerebral cortex, hippocampus, thalamus, and remaining brain tissues of the chronic unpredictable mild stress (CUMS) rat model of depression. Rats were divided into the following two groups (n = 6 in each group): (1) control group, (2) CUMS group. The CUMS stress procedure lasted for 4 weeks. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test |
Sample size | 12 |
Tissue | Central; Brain; Cerebral cortex; Central; Brain; Hippocampus; Central; Brain; Thalamus; Central; Brain; Brain; |
Platform | MS-based; GC-MS: Agilent 6890N gas chromatography coupled with Agilent 5975B inert MSD mass spectrometry; |
PMID | |
DOI | |
Citation | Ni Y, Su M, Lin J, et al. Metabolic profiling reveals disorder of amino acid metabolism in four brain regions from a rat model of chronic unpredictable mild stress. FEBS Lett 2008;582(17):2627-36. |
Metabolite | Imidazoleacetic acid; Methylimidazoleacetic acid; N-Acetyl-L-aspartic acid; L-Phenylalanine; L-Cysteine; L-Tryptophan; L-Valine; L-Leucine; L-Proline; L-Glutamic acid; Glycine; L-Serine; L-Threonine; Arachidonic acid; L-Isoleucine; L-Methionine; |
