Study M972
Study name | Zhao DP 2022 |
Title | Study of antidepressant-like effects of albiflorin and paeoniflorin through metabolomics from the perspective of cancer-related depression |
Overall design | The aim of this study was to investigate whether albiflorin and paeoniflorinn are able to exert antidepressant-like effects and understand the underlying mechanisms in a rat model, established by combining irradiation with chronic restraint stress (CRS) and solitary confinement. Sprague-Dawley rats were divided into the following 5 groups (n = 8 in each group): (1) control group, (2) CRS + irradiation group (CRS with radiotherapy), (3) CRS + irradiation + Paeoniae Radix Alba group (CRS with radiotherapy, plus Paeoniae Radix Alba treatment at the dose of 2 g/kg), (4) CRS + irradiation + albiflorin group (CRS with radiotherapy, plus albiflorin treatment at the dose of 30 mg/kg), and (5) CRS + irradiation + paeoniflorin group (CRS with radiotherapy, plus paeoniflorin treatment at the dose of 30 mg/kg). The CRS stress procedure lasted for 3 weeks (3h for each day), and drugs were administered via intragastric during the model building period. Metabonomics analysis was used to explore the underlying mechanisms of albiflorin and paeoniflorin in serum and cerebral cortex samples. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Sucrose preference test |
Sample size | 40 |
Tissue | Central; Brain; Cerebral cortex; Peripheral; Blood; Serum; |
Platform | MS-based; LC-MS: Thermo Scientific Q Exactive hybrid quadrupole Orbitrap mass spectrometer; |
PMID | |
DOI | |
Citation | Zhao D, Zhang J, Zhu Y, et al. Study of antidepressant-like effects of albiflorin and paeoniflorin through metabolomics from the perspective of cancer-related depression. Front Neurol. 2022 Jul 8;13:828612. |
Metabolite | Pyroglutamic acid; L-Asparagine; L-Glutamine; L-Kynurenine; Butyrylcarnitine; 4-Hydroxyproline; Citrulline; L-Carnitine; LysoPC(22:4); L-Octanoylcarnitine; LysoPC(O-18:0); LysoPC(24:0/0:0); LysoPE(0:0/18:2); LysoPE(18:1/0:0); LysoPC(20:2); Tiglylcarnitine; LysoPC(P-18:0/0:0); Valerylcarnitine; 3-hydroxyhexadecanoyl carnitine; CE(20:5); TG(18:1/22:5/22:6); TG(18:1/22:6/22:4); LysoPE(22:6/0:0); Heptanoylcarnitine; |
