Study M969
Study name | Zhang SF 2022 |
Title | Effects of Changyu Daotan Decoction on depression via restoration of mice hippocampus and alteration of expression of relevant neurotrophic factors |
Overall design | The aim of this study was to investigate the therapeutic effect of Changyu Daotan Decoction in the chronic unpredictable mild stress (CUMS) model of depression. ICR mice were divided into the following 4 groups (n = 10 in each group): (1) control group, (2) CUMS group, (3) CUMS + Changyu Daotan Decoction group (stressor plus Changyu Daotan Decoction treatment at the dose of 3.9 g/kg), and (4) CUMS + sertraline group (stressor plus sertraline treatment at the dose of 0.83 mg/kg). The CUMS stress procedure lasted for 3 weeks, and drugs were administered for 3 weeks after stress via intragastric. Three hippocampal samples per group were used for metabonomic analysis. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Mouse; ICR mouse; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test, forced swimming test, tail suspension test |
Sample size | 12 |
Tissue | Central; Brain; Hippocampus; |
Platform | MS-based; LC-MS: not reported; |
PMID | |
DOI | |
Citation | Zhang S, Chen Q, Wu L, et al. Effects of Changyu Daotan Decoction on depression via restoration of mice hippocampus and alteration of expression of relevant neurotrophic factors. Evid Based Complement Alternat Med. 2022 Aug 29;2022:5750647. |
Metabolite | Gamma-Aminobutyric acid; |
