Study M927
Study name | Zhang Y 2022a |
Title | Zhi-zi-chi decoction reverses depressive behaviors in CUMS rats by reducing oxidative stress injury via regulating GSH/GSSG pathway |
Overall design | The aim of this study was to explore the antidepressant mechanism and efficacy material basis of Zhi-zi-chi decoction in the chronic unpredictable mild stress (CUMS) model of depression. Sprague-Dawley rats were divided into the following 3 groups (n = 8 in each group): (1) control group, (2) CUMS group, and (3) CUMS + Zhi-zi-chi decoction group (stressor plus Zhi-zi-chi decoction treatment at the dose of 5 g/kg). The CUMS stress procedure lasted for 7 weeks, and drugs were administered via intragastric once per day during the last 2 weeks of the model building period. The brain metabolic profile of depressed rats was analyzed by the method of metabolomics based on ultra-performance liquid chromatography-quadrupole/time-of-flight mass. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test, forced swimming test, tail suspension test |
Sample size | 24 |
Tissue | Central; Brain; Brain; |
Platform | MS-based; LC-MS: Agilent 1,260/6,538 UHD Accurate-Mass Q-TOF LC/MS system (Agilent, United States); |
PMID | |
DOI | |
Citation | Zhang Y, Fang YC, Cui LX, et al. Zhi-zi-chi decoction reverses depressive behaviors in CUMS rats by reducing oxidative stress injury via regulating GSH/GSSG pathway. Front Pharmacol. 2022 Apr 7;13:887890. |
Metabolite | L-Phenylalanine; L-Tryptophan; L-Leucine; L-Methionine; L-Lysine; Pantothenic acid; Creatinine; D-Ribose; Inosine; Dopamine; S-Adenosylhomocysteine; Oxidized glutathione; Glycerophosphocholine; Aminoadipic acid; Adenine; Cytidine; Cytosine; Glutathione; Guanosine; Sphingosine; |
