Study M924
Study name | Liu XY 2022 |
Title | Serum metabolomic responses to aerobic exercise in rats under chronic unpredictable mild stress |
Overall design | The aim of this study was to reveal the modulation of the serum metabolic profile of chronic unpredictable mild stress (CUMS) model of depressive rats by aerobic exercise using an LC-MS/MS metabolomics approach. Sprague-Dawley rats were divided into the following 3 groups (n = 8 in each group): (1) control group (no stress, no aerobic exercise), (2) CUMS group (stress, no aerobic exercise), and (3) CUMS + aerobic exercise group (stress, with aerobic exercise). The CUMS stress procedure lasted for 7 weeks, and aerobic exercise was performed during the last 4 weeks of the model building period. Eight serum samples per group were used for metabonomic analysis. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test |
Sample size | 24 |
Tissue | Peripheral; Blood; Serum; |
Platform | MS-based; LC-MS: Thermo-Fisher ultra-performance liquid chromatography system (UHPLC) (Thermo-Fisher, USA) with Q Exactive Orbitrap-MS (Thermo-Fisher, USA); |
PMID | |
DOI | |
Citation | Liu X, Han Y, Zhou S, et al. Serum metabolomic responses to aerobic exercise in rats under chronic unpredictable mild stress. Sci Rep. 2022 Mar 22;12(1):4888. |
Metabolite | Citric acid; L-Phenylalanine; L-Tryptophan; L-Valine; L-Proline; L-Isoleucine; L-Methionine; L-Lysine; Hippuric acid; D-Glucose; Choline; Taurine; Pyruvic acid; |
