Study M883
Study name | Zhao HY 2022 |
Title | A pilot exploration of multi-omics research of gut microbiome in major depressive disorders |
Overall design | The aim of this study was to explore the connection between the microbiome metagenomics, immunology, metabolomics, and brain structure in major depressive disorders (MDD). The data of metabolomic, metagenomics, inflammatory factors, and MRI scanning are collected from the two groups including drug-naive MDD patients (MDD group, n =24) and healthy controls (control group, n = 26). Blood samples were used for LC-MS-based metabolomic analysis. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-5 diagnosed MDD, HAMD-17 > 17 |
Sample size | 50 |
Tissue | Peripheral; Blood; Blood; |
Platform | MS-based; LC-MS: ExionLC AD system (SCIEX) coupled with a QTRAP 6500+ mass spectrometer (SCIEX); |
PMID | |
DOI | |
Citation | Zhao H, Jin K, Jiang C, et al. A pilot exploration of multi-omics research of gut microbiome in major depressive disorders. Transl Psychiatry. 2022 Jan 10;12(1):8. |
Metabolite | Linoleic acid; Cholic acid; Xanthine; Taurine; Niacinamide; Dihydroxyacetone phosphate; L-Malic acid; Adenosine monophosphate; Glycerophosphocholine; Glycocholic acid; Phosphoenolpyruvic acid; ADP; LysoPE(18:0); Spermidine; Cytidine monophosphate; O-Phosphoethanolamine; 10E,12Z-Octadecadienoic acid; gamma-Glutamylglutamic acid; Galactinol; Vitamin A; All-trans-13,14-dihydroretinol; Hypogeic acid; (2R,3R)-2-Aminooctadecane-1,3-diol; D-Mannose 6-phosphoate; D-malic acid; 3'-aenylic acid; Picolinamide; N'-feruloyl putrescine; Niflumic acid; |
