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Study M839

Study name

Kubo H 2021

Title

Plasma acetylcholine and nicotinic acid are correlated with focused preference for photographed females in depressed males: an economic game study

Overall design

The aim of this study was to investigate major depressive disorder (MDD) patients’ trusting behaviors and preference for others using our PC-based trust game, and is to explore the biological basis by evaluating blood biomarkers. A total of 38 drug-free MDD patients (MDD group) were selected for the present study, and 38 healthy subjects were selected as healthy controls (control group). Plasma metabolome analysis was performed for all subjects by liquid chromatography-mass spectrometry (LC-MS).

Study Type

Type1;

Data available

Unavailable

Organism

Human;

Categories of depression

Depressive disorder; Depression; Depression;

Criteria for depression

DSM-IV-TR diagnosed MDD

Sample size

76

Tissue

Peripheral; Blood; Plasma;

Platform

MS-based; LC-MS: LCMS-8060 (Shimadzu Corp., Kyoto, Japan);

PMID

33500434

DOI

10.1038/s41598-020-75115-4

Citation

Kubo H, Setoyama D, Watabe M, et al. Plasma acetylcholine and nicotinic acid are correlated with focused preference for photographed females in depressed males: an economic game study. Sci Rep. 2021 Jan 26;11(1):2199.

Metabolite

L-Tryptophan;

Glycine;

L-Serine;

L-Methionine;

L-Lactic acid;

L-Alanine;

L-Glutamine;

L-Lysine;

Succinic acid;

L-Tyrosine;

L-Arginine;

L-Cystine;

Dimethylglycine;

Creatinine;

Oxoglutaric acid;

Fumaric acid;

Pyruvic acid;

L-Histidine;

Inosine;

Norepinephrine;

Adenosine;

Guanosine monophosphate;

Adenosine monophosphate;

L-Carnitine;

Nicotinic acid;

Cytidine;

Guanosine;

Orotic acid;

Ornitine;

Asymmetric dimethylarginine;

Acetylcholine;

Aconitic acid;

Symmetric dimethylarginine;