Study M772
Study name | Li XM 2021 |
Title | Multi-omics analysis of the amygdala in a rat chronic unpredictable mild stress model of depression |
Overall design | The aim of this study was to explore changes in the amygdala in a chronic unpredictable mild stress (CUMS) rat model of depression by a combination of liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based metabolomic and isobaric tags for relative and absolute quantitation (iTRAQ) proteomic analyses. Sprague-Dawley rats were divided into the following 2 groups: (1) control group, and (2) CUMS group. The CUMS stress procedure lasted for 3 weeks. For metabolomic analysis, 11 rat samples in the CUMS group and 8 rat samples in the control group were used. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test, forced swimming test |
Sample size | 19 |
Tissue | Central; Brain; Amygdala; |
Platform | MS-based; LC-MS: not reported; |
PMID | |
DOI | |
Citation | Li X, Zhou X, Teng T, et al. Multi-omics analysis of the amygdala in a rat chronic unpredictable mild stress model of depression. Neuroscience. 2021 May 21;463:174-183. |
Metabolite | myo-Inositol; Citric acid; Linoleic acid; Pyroglutamic acid; Oleic acid; Palmitic acid; N-Acetyl-L-aspartic acid; L-Phenylalanine; L-Valine; L-Leucine; L-Glutamic acid; L-Glutamine; L-Tyrosine; L-Arginine; Uridine; Choline; Hypoxanthine; Xanthine; Taurine; Betaine; Niacinamide; Docosahexaenoic acid; Inosine; 5'-Methylthioadenosine; L-Malic acid; Phosphorylcholine; Adenine; Heptadecanoic acid; Pipecolic acid; PC(32:0); Octadecanamide; Asymmetric dimethylarginine; N-Acetylaspartylglutamic acid; LysoPC(18:0/0:0); D-Lactic acid; LysoPC(16:0/0:0); PC(18:1(9Z)/18:1(9Z)); |
