Study M760

Study name

Gao Y 2021

Title

Metabolomic analysis of the hippocampus in a rat model of chronic mild unpredictable stress-induced depression based on a pathway crosstalk and network module approach

Overall design

In this study, neurotransmitters in the hippocampus of rats with chronic unpredictable mild stress (CUMS) depression were detected. Rats were divided into the following 2 groups: (1) control group, and (2) CUMS group. Ten hippocampal samples per group were used for targeted metabonomic analysis.

Study Type

Type1;

Data available

Unavailable

Organism

Rat; Rat;

Categories of depression

Animal model; Chronic mild stress model; Chronic mild stress model;

Criteria for depression

Not reported

Sample size

20

Tissue

Central; Brain; Hippocampus;

Platform

MS-based; LC-MS: UPLC 1290 II chromatograph (Agilent, USA) with QTRAP 3200 mass spectrometer (AB SCIEX, USA);

PMID

33190083

DOI

10.1016/j.jpba.2020.113755

Citation

Gao Y, Mu J, Xu T, et al. Metabolomic analysis of the hippocampus in a rat model of chronic mild unpredictable stress-induced depression based on a pathway crosstalk and network module approach. J Pharm Biomed Anal. 2021 Jan 30;193:113755.

Metabolite

Gamma-Aminobutyric acid;

L-Tryptophan;

L-Glutamic acid;

L-Tyrosine;

Serotonin;

Dopamine;

GABA/glutamate ratio;