Study M693

Study name

Setoyama D 2021b

Title

Personality classification enhances blood metabolome analysis and biotyping for major depressive disorders: two-species investigation

Overall design

In this study, the authors obtained the plasma metabolites profiles of the chronic social defeat (SD) mice by LCMS-based metabolome analysis. C57BL/6J mice were divided into the following 2 groups (n = 8 in each group): (1) control group, and (2) SDS group (consecutive social stress for 10 consecutive days). Six plasma samples per group were used for metabonomic analysis.

Study Type

Type1;

Data available

Unavailable

Organism

Mouse; C57BL/6J mouse;

Categories of depression

Animal model; Social defeat model; Social defeat model;

Criteria for depression

Not reported

Sample size

16

Tissue

Peripheral; Blood; Plasma;

Platform

MS-based; LC-MS: LCMS 8060 instrument (Shimadzu, Japan);

PMID

33038697

DOI

10.1016/j.jad.2020.09.118

Citation

Setoyama D, Yoshino A, Takamura M, et al. Personality classification enhances blood metabolome analysis and biotyping for major depressive disorders: two-species investigation. J Affect Disord. 2021;279:20-30.

Metabolite

Gamma-Aminobutyric acid;

L-Tryptophan;

L-Proline;

L-Threonine;

L-Lactic acid;

L-Alanine;

L-Asparagine;

L-Cystine;

Citrulline;

Cytosine;