Study M689
Study name | Zhu YL 2020 |
Title | Metabolomics analysis of the antidepressant prescription Danzhi Xiaoyao Powder in a rat model of Chronic Unpredictable Mild Stress (CUMS) |
Overall design | The aim of this study was to the mechanism of the antidepressant effect of Danzhi Xiaoyao Powder on a rat model of chronic unpredictable mild stress (CUMS). Sprague-Dawley rats were divided into the following 3 groups: (1) control group, (2) CUMS group, and (3) CUMS + Danzhi Xiaoyao Powder group (stressor plus Danzhi Xiaoyao Powder treatment at the dose of 25 mg/kg). The CUMS stress procedure lasted for 4 weeks, and drugs were administered via intragastric once per day for 14 days after stress. Ten plasma samples per group were used for metabonomic analysis. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test, forced swimming test |
Sample size | 30 |
Tissue | Peripheral; Blood; Plasma; |
Platform | MS-based; LC-MS: Agilent 1290 Infinity LC Ultra High Performance Liquid Chromatography System (UPLC) with mass spectrometry; |
PMID | |
DOI | |
Citation | Zhu YL, Li SL, Zhu CY, et al. Metabolomics analysis of the antidepressant prescription Danzhi Xiaoyao Powder in a rat model of Chronic Unpredictable Mild Stress (CUMS). J Ethnopharmacol. 2020;260:112832. |
Metabolite | L-Tyrosine; Bilirubin; Cholic acid; Phenylacetylglycine; Xanthine; Dopamine; Behenic acid; Corticosterone; Cortisol; L-Palmitoylcarnitine; 2-Methyl-3-hydroxybutyric acid; Prostaglandin E2; LysoPE(18:0/0:0); D-Ornithine; Glycyrrhetinic acid; Phenol; 11-Deoxysitosterol; Salicylic acid; Stearic acarnitine; 17-beta-Estradiol glucuronide; Estrone glucuronide; |
