Study M684
Study name | Zhang K 2020 |
Title | Electroacupuncture relieves LPS-induced depression-like behaviour in rats through IDO-mediated tryptophan-degrading pathway |
Overall design | The aim of this study was to observe the effects of electroacupuncture on depression-like behaviour in lipopolysaccharide (LPS)-treated rats and the underlying mechanism. Wistar rats were divided into the following 3 groups (n = 8 in each group): (1) control group (vehicle injection), (2) LPS group (LPS intraperitoneal injection for 1 week, 0.5 mg/kg), and (3) LPS + electroacupuncture group (LPS injection plus electroacupuncture treatment for 1 week). Tryptophan, 5-hydroxytryptamine, kynurenine and quinolinic acid were detected by ultra-high-performance liquid chromatography-tandem mass spectrometry (n = 6 per group). |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Rat; Wistar rat; |
Categories of depression | Animal model; Lipopolysaccharide induced depression model; Lipopolysaccharide induced depression model; |
Criteria for depression | Sucrose preference test, forced swimming test |
Sample size | 18 |
Tissue | Central; Brain; Hippocampus; |
Platform | MS-based; LC-MS: Agilent 1290 Infinity II UHPLC system coupled to 6470A triple quadrupole mass spectrometer (Santa Clara, CA, United States); |
PMID | |
DOI | |
Citation | Zhang K, Liu R, Gao Y, et al. Electroacupuncture relieves LPS-induced depression-like behaviour in rats through IDO-mediated tryptophan-degrading pathway. Neuropsychiatr Dis Treat. 2020;16:2257-2266. |
Metabolite |
