Study M663
Study name | Wang T 2020 |
Title | Diterpene ginkgolides exert an antidepressant effect through the NT3-TrkA and Ras-MAPK pathways |
Overall design | In this study, depression-related behavioral tests were used to evaluate the antidepressant-like effect of diterpene ginkgolides on rats. Sprague-Dawley rats were divided into the following 2 groups (n = 15 in each group): (1) control group (vehicle injection), and (2) diterpene ginkgolides group (diterpene ginkgolides meglumine injection treatment at the dose of 5.4 mg/kg for 4 weeks). The non-targeted metabolomics approach, based on gas chromatography-mass spectrometry (GC-MS), was used to obtain total metabolic data for the hippocampus and prefrontal cortex. |
Study Type | Type3; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Healthy individuals; Healthy individuals; Healthy individuals; |
Criteria for depression | Forced swimming test, tail suspension test |
Sample size | 30 |
Tissue | Central; Brain; Hippocampus; Central; Brain; Prefrontal cortex; |
Platform | MS-based; GC-MS: Agilent 7890A/5975C GC/MSD system (splitless mode; Agilent Technologies, Santa Clara, California, USA); |
PMID | |
DOI | |
Citation | Wang T, Bai S, Wang W, et al. Diterpene ginkgolides exert an antidepressant effect through the NT3-TrkA and Ras-MAPK pathways. Drug Des Devel Ther. 2020;14:1279-1294. |
Metabolite | myo-Inositol; Gamma-Aminobutyric acid; L-Phenylalanine; Glycine; L-Serine; L-Isoleucine; L-Lactic acid; Oxalic acid; D-Glucose; Urea; Spermine; Fumaric acid; Fructose 6-phosphate; Ethanolamine; Creatine; Beta-Alanine; Glycolic acid; 5-Thymidylic acid; Adenosine; Allantoic acid; Adenine; Sucrose; Malonic acid; Ribitol; 6-Phosphogluconic acid; D-Alanyl-D-alanine; Cytidine monophosphate; Phosphate; O-Phosphoethanolamine; 2-Hydroxypyridine; Methyl palmitoleate; 11Z-Eicosenoic acid; N-Methylhydantoin; Aspirin; Aniline; Nicotinuric acid; Monoethylhexyl phthalic acid; |
