Study M661
Study name | Wang M 2020 |
Title | Amino acid metabolism, lipid metabolism, and oxidative stress are associated with post-stroke depression: a metabonomics study |
Overall design | The aim of this study was to perform a liquid chromatography (LC)-MS-based metabolomics study of the plasma metabolite profiles between patients with post-stroke depression (PSD) and controls. Ten stroke patients without PSD (stroke group) and 10 stroke patients with PSD (PSD group) were recruited. Plasma metabolite biomarkers were identified by LC-MS. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Post-stroke depression; Post-stroke depression; |
Criteria for depression | DSM-5 diagnosed MDD, HAMD-17 > 7 |
Sample size | 20 |
Tissue | Peripheral; Blood; Plasma; |
Platform | MS-based; LC-MS: 1290 Ultra High Performance Liquid Chromatography (Agilent Technologies, Santa Clara, CA, USA) and Triple TOF 6600 High Resolution Mass Spectrometer (AB SCIEX LLC, Framingham, MA, USA); |
PMID | |
DOI | |
Citation | Wang M, Gui X, Wu L, et al. Amino acid metabolism, lipid metabolism, and oxidative stress are associated with post-stroke depression: a metabonomics study. BMC Neurol. 2020;20(1):250. |
Metabolite | Palmitic acid; |
