Study M630
Study name | Li W 2020 |
Title | The effect of acupuncture on depression and its correlation with metabolic alterations: a randomized controlled trial |
Overall design | In this study, the role of acupuncture in combination with antidepressants was examined through the evaluation of urine metabolomics. Patients with moderate-severe depression were divided into 2 groups (n = 30 per group): (1) acupuncture + antidepressant group (acupuncture treatment 3 times per week, 30min per session, for a period of 8 weeks, combined with routine antidepressants), and (2) antidepressant group (only routine antidepressants). Urinary metabolites were compared before and after treatment. |
Study Type | Type2; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV diagnosed MDD, HAMD-24 between 20 and 35 |
Sample size | 60 |
Tissue | Peripheral; Urine; Urine; |
Platform | MS-based; GC-MS: Agilent 7890B gas chromatography system with Agilent 5977A MSD system (Agilent, CA); |
PMID | |
DOI | |
Citation | Li W, Sun M, Yin X, et al. The effect of acupuncture on depression and its correlation with metabolic alterations: a randomized controlled trial. Medicine. 2020;99(43):e22752. |
Metabolite | L-Tryptophan; L-Proline; L-Serine; L-Glutamine; Xanthurenic acid; Xanthine; L-Histidine; N-Acetylserotonin; Malonic acid; Dehydroascorbic acid; Glutathione; 2-Keto-L-gluconate; Orotic acid; 1-Methyladenosine; 5-Methoxyindoleacetate; |
