Study M600
Study name | Demers G 2020 |
Title | Fish oil supplementation alleviates metabolic and anxiodepressive effects of diet-induced obesity and associated changes in brain lipid composition in mice |
Overall design | The aim of this study was to explore the effects of omega-3 polyunsaturated fatty acids (n-3 PUFA) supplementation on energy homeostasis, anxiodepressive behavior, brain lipid composition, and gliosis in the diet-induced obese state. C57BL/6J mice were divided into the following 4 groups (n = 12 in each group): (1) control group (control diet with control corn oil), (2) high-fat diet group (high-fat diet with control corn oil), (3) fish oil group (control diet with fish oil supplementation), and (4) high-fat diet + fish oil group (high-fat diet with fish oil supplementation). Mice were fed a saturated high-fat diet or chow for 20 weeks. During the last 5 weeks of the diet protocol, mice from the high-fat diet and chow groups received daily gavage of fish oil or control corn oil. In the forced swimming test, high-fat diet enhanced behavioral despair, and fish oil reduced immobility time in high-fat diet mice. Forebrain lipid composition was assessed by gas chromatography-mass spectrometry (n = 4-12 per group). |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Mouse; C57BL/6J mouse; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Forced swimming test |
Sample size | 39 |
Tissue | Central; Brain; Forebrain; |
Platform | MS-based; GC-MS: 7890B gas chromatograph with 5977A Mass Selective Detector (Agilent Technologies, Santa Clara, USA); |
PMID | |
DOI | |
Citation | Demers G, Roy J, Machuca-Parra AI, et al. Fish oil supplementation alleviates metabolic and anxiodepressive effects of diet-induced obesity and associated changes in brain lipid composition in mice. Int J Obes. 2020;44(9):1936-1945. |
Metabolite | Linoleic acid; Myristic acid; Arachidonic acid; |
