Study M571
Study name | Wu Y 2019 |
Title | Perturbation of Ephrin receptor signaling and glutamatergic transmission in the hypothalamus in depression using proteomics integrated with metabolomics |
Overall design | In this study, gas chromatography-mass spectrometry was employed to detect the metabolomes in the hypothalamus of the lipopolysaccharide (LPS)-induced depression mouse. CD-1 mice were divided into the following 2 groups: (1) control group, and (2) LPS group (i.p. at a dose of 0.83 mg/kg). Ten samples per group were used for metabolomics analysis. |
Study Type | Type1; |
Data available | |
Organism | Mouse; CD-1 mouse; |
Categories of depression | Animal model; Lipopolysaccharide induced depression model; Lipopolysaccharide induced depression model; |
Criteria for depression | Sucrose preference test, forced swimming test, tail suspension test |
Sample size | 20 |
Tissue | Central; Brain; Hypothalamus; |
Platform | MS-based; GC-MS: not reported; |
PMID | |
DOI | |
Citation | Wu Y, Wei Z, Li Y, et al. Perturbation of Ephrin receptor signaling and glutamatergic transmission in the hypothalamus in depression using proteomics integrated with metabolomics. Front Neurosci. 2019;13:1359. |
Metabolite | myo-Inositol; Gamma-Aminobutyric acid; L-Cysteine; L-Tryptophan; L-Proline; L-Threonine; L-Alanine; L-Glutamine; L-Aspartic acid; Succinic acid; Urea; Phytosphingosine; Hydroxylamine; Hypoxanthine; Vanillylmandelic acid; DOPA; L-Histidine; Niacinamide; Inosine; Adenosine monophosphate; 3-Aminoisobutanoic acid; |
