Study M175
Study name | Schwieler L 2016 |
Title | Electroconvulsive therapy suppresses the neurotoxic branch of the kynurenine pathway in treatment-resistant depressed patients |
Overall design | The aim of the present study is to investigate the peripheral concentration of cytokines and tryptophan and kynurenine metabolites in patients with unipolar treatment-resistant depression before and after electroconvulsive therapy (ECT), the most effective treatment for depression. Tryptophan, kynurenine, and quinolinic acid in plasma from patients with major depressive disorder (MDD group; n = 19) and healthy volunteers (control group; n = 14) were detected with high-performance liquid chromatography (HPLC) and LC/MS. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Treatment-resistant depression; Treatment-resistant depression; |
Criteria for depression | Mini-International Neuropsychiatric Interview (MINI) diagnosed MDD or Montgomery-Asberg Depression Rating Scale (MADRS) |
Sample size | 33 |
Tissue | Peripheral; Blood; Plasma; |
Platform | MS-based; LC-MS: Waters Acquity HPLC system with Waters Xevo TQ triple quadrupole mass spectrometer; |
PMID | |
DOI | |
Citation | Schwieler L, Samuelsson M, Frye MA, et al. Electroconvulsive therapy suppresses the neurotoxic branch of the kynurenine pathway in treatment-resistant depressed patients. J Neuroinflammation 2016;13(1):51. |
Metabolite |
