Study M115
Study name | Umehara H 2017 |
Title | Altered KYN/TRP, Gln/Glu, and Met/methionine sulfoxide ratios in the blood plasma of medication-free patients with major depressive disorder |
Overall design | In the present study, CE-TOFMS was used to profile metabolites found in the blood plasma of 33 medication-free patients with medication-free major depressive disorder (MDD group) and 33 non-psychiatric control subjects (control group). Changes which occurred in the metabolite levels during an 8-week treatment period (MDD treated group, n = 10) were investigated. Ten patients received a naturalistic course of treatment with an antidepressant (paroxetine n = 4, duloxetine n = 2, mirtazapine n = 1, or sertraline n = 3). |
Study Type | Type1; Type2; |
Data available | |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV diagnosed MDD |
Sample size | 66 |
Tissue | Peripheral; Blood; Plasma; |
Platform | MS-based; CE-MS: not reported; |
PMID | |
DOI | |
Citation | Umehara H, Numata S, Watanabe SY, et al. Altered KYN/TRP, Gln/Glu, and Met/methionine sulfoxide ratios in the blood plasma of medication-free patients with major depressive disorder. Sci Rep 2017;7(1):4855. |
Metabolite | Glyceric acid; Pyroglutamic acid; L-Glutamic acid; L-Methionine; L-Asparagine; L-Glutamine; L-Aspartic acid; Hippuric acid; Uridine; L-Cystine; L-Kynurenine; Threonic acid; Creatinine; Hypoxanthine; Uric acid; Glucose 6-phosphate; Ethanolamine; 2-Hydroxybutyric acid; cis-Aconitic acid; Isocitric acid; 3-Phosphoglyceric acid; L-Acetylcarnitine; Phosphorylcholine; Glycerophosphocholine; Inosinic acid; Glutamine/Glutamate ratio; Kynurenine/Tryptophan ratio; Methionine sulfoxide; 2-Aminoisobutyric acid; 2(N)-Methyl-norsalsolinol; Methylcysteine; Thiaproline; 1-Methyladenosine; |
