Study M1138
Study name | Carneiro CA 2022 |
Title | Unpredictable subchronic stress induces depressive-like behavior: behavioral and neurochemical evidences |
Overall design | The aim of this study was to evaluate whether unpredictable subchronic stress (USS) model could induce depressive-like behavior and neurochemical changes related to depression, and be prevented by the use of antidepressants. Swiss mice were divided into the following 3 groups: (1) control group (non-stress with vehicle treatment), (2) unpredictable subchronic stress group (stress with vehicle treatment), and (3) unpredictable subchronic stress + imipramine group (stress with imipramine treatment at the dose of 15 mg/kg). The USS stress procedure lasted for 2 weeks, and drugs were administered via intragastric during the last 6 days of the model building period. The levels of neurotransmitters in the hippocampus were measured by GC-MS (n= 7-8 in each group). |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Mouse; Swiss mouse; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Tail suspension test |
Sample size | 22 |
Tissue | Central; Brain; Hippocampus; |
Platform | MS-based; GC-MS: Shimadzu QP2010 Ultra GC-MS system (Shimadzu Corporation, Kyoto, Japan); |
PMID | |
DOI | |
Citation | Carneiro CA, Santos AMF, Guedes EC, et al. Unpredictable subchronic stress induces depressive-like behavior: behavioral and neurochemical evidences. Psychology and Neuroscience 2022;15(3):236-250. |
Metabolite | Gamma-Aminobutyric acid; L-Tryptophan; 5-Hydroxyindoleacetic acid; 5-HIAA/5-HT ratio; |
