Study M1111
Study name | Zhou CH 2023b |
Title | rTMS ameliorates depressive-like behaviors and regulates the gut microbiome and medium- and long-chain fatty acids in mice exposed to chronic unpredictable mild stress |
Overall design | The aim of this study was to determine the influence of repetitive transcranial magnetic stimulation (rTMS) on the composition of medium- and long-chain fatty acids in the plasma, prefrontal cortex, and hippocampus as well as the composition of gut microbiota in the chronic unpredictable mild stress (CUMS) model of depression. C57BL/6 mice were divided into the following 4 groups: (1) control group (non-stress with sham rTMS treatment), (2) rTMS group (non-stress with rTMS treatment), (3) CUMS group (stress with sham rTMS treatment), and (4) CUMS + rTMS group (stress with rTMS treatment). Mice in the CUMS groups were stressed for 4 weeks, then mice received sham rTMS or real rTMS for 7 days. Plasma, hippocampus, and prefrontal cortex samples of each group were used for fatty acid detection by GC-MS (n =8/group). |
Study Type | Type1; Type2; Type3; |
Data available | Unavailable |
Organism | Mouse; C57BL/6 mouse; |
Categories of depression | Healthy individuals; Healthy individuals; Healthy individuals; Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test, tail suspension test |
Sample size | 32 |
Tissue | Peripheral; Blood; Plasma; Central; Brain; Prefrontal cortex; Central; Brain; Hippocampus; |
Platform | MS-based; GC-MS: Agilent 7890A/5975C system; |
PMID | |
DOI | |
Citation | Zhou CH, Chen YH, Xue SS, et al. rTMS ameliorates depressive-like behaviors and regulates the gut microbiome and medium- and long-chain fatty acids in mice exposed to chronic unpredictable mild stress. CNS Neurosci Ther. 2023 Jun 2. |
Metabolite | Linoleic acid; Oleic acid; Arachidonic acid; Docosahexaenoic acid; Elaidic acid; Heptadecanoic acid; Caprylic acid; Arachidic acid; Alpha-Linolenic acid; Dodecanoic acid; Capric acid; Eicosapentaenoic acid; Docosapentaenoic acid (22n-3); Dihomo-gamma-linolenic acid; Gamma-Linolenic acid; Linoelaidic acid; Pentadecanoic acid; Undecanoic acid; Tricosanoic acid; Dihomo-alpha-linolenic acid; Docosatetraenoic acid; |
