Study M1095

Study name

Zhang M 2023

Title

Matrine alleviates depressive-like behaviors via modulating microbiota-gut-brain axis in CUMS-induced mice

Overall design

The aim of this study was to investigate the underlying mechanisms of matrine on the depression-like behavior of chronic unpredictable mild stress (CUMS) mice model of depression. ICR mice were divided into the following 3 groups (n = 10 in each group): (1) control group, (2) CUMS group, and (3) CUMS + matrine group (stress with matrine treatment at the dose of 30 mg/kg). The CUMS stress procedure lasted for 6 weeks, and matrine was administered via intragastric once per day during the last 2 weeks of the model building period. The effect of matrine on gut metabolites was further explored using LC-MS-based metabolomics analysis (n = 8/group).

Study Type

Type1;

Type2;

Data available

Unavailable

Organism

Mouse; ICR mouse;

Categories of depression

Animal model; Chronic mild stress model; Chronic mild stress model;

Criteria for depression

Sucrose preference test, forced swimming test

Sample size

24

Tissue

Peripheral; Faece; Faece;

Platform

MS-based; LC-MS: UPLC-QTOF-MS (Triple TOF 5600+, SCIEX, USA);

PMID

36829227

DOI

10.1186/s12967-023-03993-z

Citation

Zhang M, Li A, Yang Q, et al. Matrine alleviates depressive-like behaviors via modulating microbiota-gut-brain axis in CUMS-induced mice. J Transl Med. 2023 Feb 24;21(1):145.

Metabolite

L-Phenylalanine;

L-Tryptophan;

L-Glutamine;

L-Tyrosine;

Serotonin;

Histamine;

Norepinephrine;

Citrulline;

Dopamine;

N-Acetylserotonin;

Glucosamine 6-phosphate;

4-Pyridoxic acid;

Acetylphosphate;

Galactinol;

Pyridoxal;

Acamprosate;

D-Maltose;

N6,N6,N6-Trimethyl-L-lysine;

4-Morpholinopropanesulfonic acid;

(N-(-2-Acetamido))-2-aminoethanesulfonic acid;

Uridine diphosphategalactose;

Cellobiose;

Glu-Gly-Arg;

N-(2-Acetamido)iminodiacetic acid;

Glu-Val-Arg;

Trp(O)-Ile;

Rosiglitazone;

D-Pipecolic acid;

PyroGlu-Trp-Lys;

His-Met-Arg;

N4-Acetylcytidine;

Gln-Trp-Arg;

Met-Val-Lys;

Ser-Asn-Lys;

Asn-Glu-Lys;

Tyr-Tyr-Arg;

Thr-Ser-Lys;

Dacarbazine;

Tyr-Ser-Lys;

Tyr-Thr-Lys;

PyroGlu-Trp-Arg;

Thr-Gly-Lys;

Phenylalanylphenylalanine;

Ser-Thr-Lys;