Study M1092
Study name | Brivio P 2023b |
Title | Venlafaxine's effect on resilience to stress is associated with a shift in the balance between glucose and fatty acid utilization |
Overall design | The aim of this study was to explore whether venlafaxine would be able to normalize the depressive-like behaviour by modulating brain metabolism in the chronic mild stress (CMS) model of depression. Wistar rats were divided into the following 4 groups: (1) control group (non-stress with vehicle treatment), (2) CMS group (stress with vehicle treatment), (3) venlafaxine group (non-stress with venlafaxine treatment at the dose of 10 mg/kg), and (4) CMS + venlafaxine group (stress with venlafaxine treatment at the dose of 10 mg/kg). The CMS stress procedure lasted for 6 weeks, and drugs were administered via I.P. once per day during the last 3 weeks of the model building period. Metabolomic changes in the ventral hippocampus were investigated using targeted LC-MS/MS metabolomics (n = 8 in each group). |
Study Type | Type1; Type2; Type3; |
Data available | Unavailable |
Organism | Rat; Wistar rat; |
Categories of depression | Healthy individuals; Healthy individuals; Healthy individuals; Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test |
Sample size | 32 |
Tissue | Central; Brain; Ventral hippocampus; |
Platform | MS-based; LC-MS: ExionLC AC System (AB Sciex, Framingham, MA, USA) with API-3500 triple quadrupole mass spectrometer (AB Sciex, Framingham, MA, USA); |
PMID | |
DOI | |
Citation | Brivio P, Audano M, Gallo MT, et al. Venlafaxine's effect on resilience to stress is associated with a shift in the balance between glucose and fatty acid utilization. Neuropsychopharmacology. 2023 Jun 28. |
Metabolite | L-Tryptophan; L-Proline; L-Serine; L-Methionine; L-Lactic acid; L-Lysine; Succinic acid; L-Tyrosine; D-Glucose; DOPA; Fumaric acid; L-Histidine; Histamine; Cyclic AMP; Cytidine triphosphate; Uridine triphosphate; NAD; Deoxyadenosine monophosphate; Adenosine monophosphate; Oxidized glutathione; Aminoadipic acid; L-Carnitine; Uridine 5'-monophosphate; D-Erythrose 4-phosphate; 6-Phosphogluconic acid; Spermidine; Guanosine diphosphate; Carnitine C4; |
