Study M1091
Study name | Brivio P 2023a |
Title | Venlafaxine's effect on resilience to stress is associated with a shift in the balance between glucose and fatty acid utilization |
Overall design | The aim of this study was to establish if differences in energy metabolite concentration may underlie the vulnerability and resilience in the chronic mild stress (CMS) model of depression. Wistar rats were divided into the following 3 groups: (1) control group, (2) CMS vulnerable group, and (3) CMS resilient group. The CMS stress procedure lasted for 6 weeks. Stressed rats were divided into the vulnerable and resilient groups based on the sucrose preference test. Metabolomic changes in the ventral hippocampus were investigated using targeted LC-MS/MS metabolomics (n = 8 in each group). |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Wistar rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test |
Sample size | 24 |
Tissue | Central; Brain; Ventral hippocampus; |
Platform | MS-based; LC-MS: ExionLC AC System (AB Sciex, Framingham, MA, USA) with API-3500 triple quadrupole mass spectrometer (AB Sciex, Framingham, MA, USA); |
PMID | |
DOI | |
Citation | Brivio P, Audano M, Gallo MT, et al. Venlafaxine's effect on resilience to stress is associated with a shift in the balance between glucose and fatty acid utilization. Neuropsychopharmacology. 2023 Jun 28. |
Metabolite | L-Tryptophan; L-Proline; L-Glutamic acid; L-Methionine; Succinic acid; L-Tyrosine; D-Glucose; DOPA; Fumaric acid; L-Histidine; Cyclic AMP; Uridine triphosphate; NAD; Deoxyadenosine monophosphate; 2'-Deoxyguanosine 5'-monophosphate; Adenosine monophosphate; Oxidized glutathione; Aminoadipic acid; L-Carnitine; Acetyl-CoA; Uridine 5'-monophosphate; D-Erythrose 4-phosphate; |
