Study M1056
Study name | Kumei S 2023 |
Title | Prostaglandin I2 suppresses the development of gut-brain axis disorder in irritable bowel syndrome in rats |
Overall design | The aim of this study was to clarify the mechanism of the effect of beraprost, a specific prostaglandin I2 agonist, in the maternal separation model. Sprague-Dawley rats were divided into the following 3 groups: (1) control group, (2) maternal separation group, and (3) maternal separation + beraprost group (maternal separation plus beraprost treatment at the dose of 1.0 mg/kg). During the period of postnatal days 2-14, maternal separation was performed for 3 hours per day. Then beraprost was given after maternal separation until 8-week. For evaluation of depression, the forced swimming test was performed at 7-week. The duration of the immobilizing time was significantly prolonged in the maternal separation group and was greatly shortened by beraprost administration. Serum metabolome analysis were performed for each group (n = 4/group). |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Forced swimming test |
Sample size | 12 |
Tissue | Peripheral; Blood; Serum; |
Platform | MS-based; LC-MS: not reported; |
PMID | |
DOI | |
Citation | Kumei S, Ishioh M, Nozu T, et al. Prostaglandin I2 suppresses the development of gut-brain axis disorder in irritable bowel syndrome in rats. Biochim Biophys Acta Gen Subj. 2023 May;1867(5):130344. |
Metabolite | L-Valine; L-Leucine; L-Methionine; L-Alanine; L-Arginine; Dimethylglycine; Cholic acid; Taurine; Betaine; Hypotaurine; 1-Methylnicotinamide; O-Phosphoethanolamine; Methionine sulfoxide; 1-Methyladenosine; Imidazolepropionic acid; N6-Acetyl-L-lysine; Octopine; N(6)-Methyllysine; N6-Carboxymethyllysine; |
