Study M1039
Study name | Gong WX 2023 |
Title | Hepatic metabolomics combined with network pharmacology to reveal the correlation between the anti-depression effect and nourishing blood effect of Angelicae Sinensis Radix |
Overall design | In this study, hepatic metabolomics and network pharmacology were combined to explore the underlying antidepressive mechanisms of Angelicae Sinensis Radix in the chronic unpredictable mild stress (CUMS) model of depression. Sprague-Dawley rats were divided into the following 5 groups (n = 10 in each group): (1) control group, (2) CUMS group, (3) CUMS + venlafaxine group (stressor plus venlafaxine treatment), (4) CUMS + low dose of Angelicae Sinensis Radix group (stressor plus Angelicae Sinensis Radix treatment at the dose of 3.6 g/kg), and (5) CUMS + high dose of Angelicae Sinensis Radix group (stressor plus Angelicae Sinensis Radix treatment at the dose of 7.2 g/kg). After treatment for 28 days, liver samples were used for metabonomic analysis. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Not reported |
Sample size | 50 |
Tissue | Peripheral; Liver; Liver; |
Platform | MS-based; LC-MS: Dionex UltiMate 3000 UHPLC system with Q Exactive Orbitrap-MS spectrometer (Thermo Fisher Scientific Inc.,Waltham, Ma, USA); |
PMID | |
DOI | |
Citation | Gong W, Xu S, Song Y, et al. Hepatic metabolomics combined with network pharmacology to reveal the correlation between the anti-depression effect and nourishing blood effect of Angelicae Sinensis Radix. Chin J Nat Med. 2023 Mar;21(3):197-213. |
Metabolite | Citric acid; Pyroglutamic acid; L-Tryptophan; L-Proline; L-Glutamic acid; L-Lysine; L-Tyrosine; Phytosphingosine; Hypoxanthine; Taurine; Niacinamide; Gluconic acid; Ornithine; L-Malic acid; Adenosine; Oxidized glutathione; Glycocholic acid; Taurochenodesoxycholic acid; SM(d18:1/16:0); Cer(d18:1/16:0); LysoPC(18:2(9Z,12Z)); Sphinganine; LysoPE(16:0/0:0); PC(18:0/20:4(5Z,8Z,11Z,14Z)); 4-Oxoproline; Ergothioneine; Erucamide; Platelet-activating factor; |
