Study M1032
Study name | Chen CC 2023 |
Title | An integrated strategy to study the combination mechanisms of Bupleurum chinense DC and Paeonia lactiflora Pall for treating depression based on correlation analysis between serum chemical components profiles and endogenous metabolites profiles |
Overall design | The aim of this study was to explore the potential combination mechanism of Bupleurum chinense DC and Paeonia lactiflora Pall for treating depression in the chronic unpredictable mild stress (CUMS) mode of depression. Sprague-Dawley rats were divided into the following 5 groups (n = 7 in each group): (1) control group, (2) CUMS group, (3) CUMS + Bupleurum chinense DC group (stressor plus Bupleurum chinense DC treatment at the dose of 7.5 g/kg), (4) CUMS + Paeonia lactiflora Pall group (stressor plus Paeonia lactiflora Pall treatment at the dose of 7.5 g/kg), and (5) CUMS + Bupleurum chinense DC and Paeonia lactiflora Pall group (stressor plus Bupleurum chinense DC and Paeonia lactiflora Pall treatment). The CUMS stress procedure lasted for 7 weeks, and drugs were administered via intragastric once per day during the last 3 weeks of the model building period. Serum samples were used for metabonomic analysis. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test, forced swimming test |
Sample size | 35 |
Tissue | Peripheral; Blood; Serum; |
Platform | MS-based; LC-MS: Dionex UltiMate 3000 UPLC system with Q Exactive Orbitrap-MS spectrometer (Thermo Fisher, USA); |
PMID | |
DOI | |
Citation | Chen C, Tian J, Gao X, et al. An integrated strategy to study the combination mechanisms of Bupleurum chinense DC and Paeonia lactiflora Pall for treating depression based on correlation analysis between serum chemical components profiles and endogenous metabolites profiles. J Ethnopharmacol. 2023 Apr 6;305:116068. |
Metabolite | Citric acid; 3-Hydroxybutyric acid; L-Valine; L-Glutamic acid; Arachidonic acid; L-Glutamine; L-Tyrosine; L-Arginine; Pantothenic acid; Taurocholic acid; Cholic acid; Serotonin; Ascorbic acid; Taurine; Uracil; Docosahexaenoic acid; cis-Aconitic acid; Xanthosine; Citrulline; Dopamine; Ornithine; 3-Phosphoglyceric acid; L-Malic acid; L-Acetylcarnitine; Oxidized glutathione; Thymine; Taurochenodesoxycholic acid; |
