Study M102
Study name | Chen JJ 2017 |
Title | Differential urinary metabolites related with the severity of major depressive disorder |
Overall design | Here, an integrated analysis of data from our previous studies was performed to identify the differential metabolites in the urine of moderate and severe major depressive disorder (MDD) patients. A dual platform approach (NMR spectroscopy and GC-MS) was used. All the recruited MDD patients in this study were the first-episode drug-naive MDD patients. Patients with HAMD score ranged from 18 to 24 were assigned into moderate MDD group, and patients with HAMD score greater than 24 were assigned into severe MDD group. 59 moderate MDD patients and 82 HCs were recruited. Similarly, 34 severe MDD patients and 41 HCs were recruited. A urinary metabolomics method was applied. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV diagnosed MDD, HAMD-17 > 17 |
Sample size | 216 |
Tissue | Peripheral; Urine; Urine; |
Platform | NMR; NMR: Bruker AVANCE II 600 spectrometer (Rheinstetten, Germany); MS-based; GC-MS: Agilent 7980 GC system with Agilent 5975 mass selective detector (Agilent Technologies Inc., USA); |
PMID | |
DOI | |
Citation | Chen JJ, Zhou CJ, Zheng P, et al. Differential urinary metabolites related with the severity of major depressive disorder. Behav Brain Res 2017;332:280-7. |
Metabolite | Citric acid; Myristic acid; Palmitic acid; Glycine; L-Lactic acid; L-Alanine; D-Fructose; Azelaic acid; Choline; Oxoglutaric acid; Indoxyl sulfate; Hydroxylamine; Taurine; Trimethylamine N-oxide; D-Ribose; Glycerophosphocholine; Sucrose; Sorbitol; Acetone; Isobutyric acid; Formic acid; Nicotinic acid; Malonic acid; |
