Study M1005
Study name | Liu JL 2022b |
Title | Butyrate emerges as a crucial effector of Zhi-Zi-Chi decoctions to ameliorate depression via multiple pathways of brain-gut axis |
Overall design | The aim of this study was to explore whether butyrate could alleviate chronic unpredictable mild stress (CUMS)-induced depression. Sprague-Dawley rats were divided into the following 4 groups: (1) control group, (2) CUMS group, (3) CUMS + fluoxetine group (stressor plus fluoxetine treatment at the dose of 2.1 mg/kg), and (4) CUMS + butyrate group (stressor plus butyrate treatment at the dose of 30 mg/kg). The CUMS stress procedure lasted for 6 weeks, and drugs were administered via intragastric during the last 2 weeks of the model building period. The levels of neurotransmitters and amino acids in plasma, ileum, and hippocampus were detected by LC-MS (n =6/group). |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test, forced swimming test, tail suspension test |
Sample size | 24 |
Tissue | Peripheral; Gut; Ileum; Central; Brain; Hippocampus; Peripheral; Blood; Plasma; |
Platform | MS-based; LC-MS: Shimadzu LC-30 AD system with Shimadzu 9030 Accurate Mass Quadrupole Time-of-Flight mass spectrometer; |
PMID | |
DOI | |
Citation | Liu J, Fang Y, Cui L, et al. Butyrate emerges as a crucial effector of Zhi-Zi-Chi decoctions to ameliorate depression via multiple pathways of brain-gut axis. Biomed Pharmacother. 2022 May;149:112861. |
Metabolite | Gamma-Aminobutyric acid; L-Phenylalanine; L-Tryptophan; L-Proline; |
